Umzekeliso nguHunter French Health I-Gabapentin ivunyiwe ngokunyanga ukuxhuzula kunye neentlungu zentlungu, ukanti iipesenti ezingama-95 zexesha elisetyenziselwa ezinye iimeko, ngaphandle kophando olunamandla lokuyibuyisela. Ngonxibelelwano lwakutshanje kwi-overdose kunye neengxelo zokuzibulala, kutheni isasetyenziswa kakhulu?Xa umakhulu kaMary * wanqunyulwa umlenze edolweni, oogqirha bamisela i-gabapentin ngenxa yeentlungu zomlenze wakhe.
Ndikhumbula ndicinga ukuba oko kwakungaqhelekanga, watsho uMary, kuba yena naye wayenommiselo ka-gabapentin. UMary uneminyaka engama-28, kwaye uthathe eli chiza-amayeza enziwe afana nalawo aveliswe ngumenzi nawo athengiswa njenge-Neurontin-phantse ishumi leminyaka. Ugqirha wakhe wamnika ukuba alinganise iziphumo zonyango lwe-ADHD, i-Concerta. Kutheni le nto kukho into endiyithathayo ukuthatha umda kwichiza le-ADHD nalo linikwa amputee? Wazibuza.
Ngaphandle kwento yokuba kukho uhlolo olutsha kwi-gabapentin, inani labantu abathathayo liyaqhubeka nokunyuka. E-United States, ukusetyenziswa kwayo ngaphezu kokuphindwe kathathu phakathi kuka-2002 no-2015. IGabapentin ibiyi I-10th yeyona mayeza aqhelekileyo amiselweyo ngo-2017, xa phantse yayizizigidi ezingama-70 zokumiselwa-ngaphezulu kwe-amoxicillin, enye yezona zinto zichazwa rhoqo.
Uninzi lwemigqaliselo ye-gabapentin yeyokusetyenziswa kwelebheli engekho mthethweni, okanye ukusetyenziswa okungavunyelwanga yi-FDA-kuqikelelwa 95 pesenti , ngophando lwedatha yelizwe liphela. Nye uphando ifumanise ukuba i-gabapentin inelona nani liphezulu lemiyalelo engekho kwileyibhile kwii-160 iziyobisi ezisetyenziswa ngokuxhaphakileyo.
La manani makhulu ngendlela engathethekiyo, utshilo uChris Goodman, unjingalwazi oncedisayo kunyango lwangaphakathi kwiYunivesithi yaseSouth Carolina School of Medicine, opapashe amaphepha amabini avavanya ukusetyenziswa kwe-gabapentin e-US Akukho zinto ziyilwe kakuhle, Uvavanyo lwe-placebo olulawulwa lunyango lwezicelo zalo ezingekho kwilebheli, utshilo uJoe Ross, ugqirha ophambili wezonyango kwiYunivesithi yaseYale kunye nomphandi ngomgaqo-nkqubo wamayeza. Ukusetyenziswa kwelebheli enye kunokuba nesifundo esinye okanye ezibini, kodwa iziphumo zinokuthozama okanye azingqinelani-zizonke, kuphela malunga neepesenti ezingama-20 ze-gabapentin kunye ne-apos; ukusetyenziswa kwelebheli kunedatha ebancedayo, utshilo uRoss.
Siyazi namhlanje ukuba i-gabapentin ayiboniswanga ukuba isebenzela iimeko ezininzi njengoko uParke-Davis wayefuna abantu bakholelwe. Kodwa xa oogqirha bemisela abaguli babo i-gabapentin, inokuba njalo ngaphandle kokwazi kanye le nto isetyenzisiweyo. Endaweni yoko ubukhulu becala kukhokelwa ngengxoxo engacwangciswanga kunye noogxa okanye iintlanganiso zobungcali, ngokuchaseneyo nokuvavanywa kommiselo kokufaneleka kwayo kwisalathiso esinikiweyo, ngokwe-2018 ukufunda Ukusetyenziswa kwelebapentin ngaphandle kwelebheli.
USeth Landefeld, usihlalo weSebe lezoNyango kwiYunivesithi yaseAlabama eBirmingham, wavuma ukuba oogqirha baya kufikelela kwi-gabapentin kwiimeko apho kunzima umntu ukuba anyange. Olu tyekelo luye lwandiswa yingxaki ye-opioid-njengoko oogqirha befuna ezinye iindlela ze-opioids, ukusetyenziswa kwe-gabapentinoid kuyanda, ngokwe uphononongo ipapashwe nguGoodman. Ubungqina bokusetyenziswa kwayo kwiintlungu zentlungu emva kwesibindi kunye nesifo sikashukela sesifo sikashukela kudala ingxelo yokuba i-gabapentin inokukunceda ngentlungu, kusho uGoodman. Ukusuka kwezi zilingo, indlu yamakhadi sele yakhiwe.
Nokuba kuvavanywa kancinci kune-gabapentin kwezinye iintlobo zentlungu yimigqaliselo yokuphazamiseka kwengqondo. Ugqirha kaMary wamxelela ukuba i-gabapentin yayilipilisi lokuxhuzula elisetyenziswa ngaphandle kwelebheli, kodwa watsho ngokuzithemba ukuba iluncedo njengesixhobo sokuqinisa imeko. UNicole, oneminyaka engama-30 ubudala ohlala eLos Angeles owayengafuni ukusebenzisa igama lakhe lokugqibela, wabelwa i-gabapentin kwisikolo samabanga aphakamileyo ngesifo sokudakumba esikhulu-ugqirha wakhe wathi i-gabapentin yayisebenza ngokuhlwa ngaphandle kwemood mood.
Kodwa izifundo ezimbalwa ezikhoyo azibanga nakho ukuwaxhasa loo mabango. Ngo-2000, babekho ezimbini ezingenamsebenzi , izilingo ezilawulwa yi-placebo ezibonisa ukuba i-gabapentin khange i sebenza ngcono kune-placebo ye-bipolar, kwaye olunye uphononongo lufumanise ukuba i-gabapentin yayi mbi kune placebos xa unyanga i-bipolar mania. Enye uphononongo kwi-gabapentin ijonge kwizifundo kwiziphumo ze-gabapentin & apos kwizifo zengqondo-ibonakalise iziphumo ezilungileyo ekunyangeni i-phobia yentlalontle, kodwa ayisebenzi kwisifo sokuphakuzela, i-OCD, okanye ukuphazamiseka kwengqondo.
Zonke iziyobisi zinobungozi kunye nezibonelelo. Xa abantu bethatha iyeza ngaphandle kobungqina obubambekayo bokuba liyasebenza, amathuba okuba bazuze kuwo ayancipha, kuba ngoku bazibeka esichengeni ngokungathethekiyo kwimingcipheko, utshilo uRoss. Ngaphandle komngcipheko onokubakho we-gabapentin, ngaba kukuziphatha okuhle ukunika isigulana iyeza elinokuthi lingenzi nto, xa linokuthi luthathe unyango olunokusebenza ngcono?
Logama oogqirha bengenayo iaposidi, ezinye iindlela ezingcono zeopioid, okanye amayeza angcono empilo yengqondo kunaleyo yokuthomalalisa uxinzelelo okanye i-benzodiazepines, i-gabapentin iya kuqhubeka nokuzalisa umsantsa. Abagqatswa bayangxama bezama ukuqonda ukuba loluphi olunye unyango olukhoyo ukunceda abaguli babo, kwaye i-gabapentin yindawo apho baphendukayo, utshilo uCovvey.